湯學成
姓名 湯學成
職稱 教授
聯絡電話 03-5742465
實驗室分機 03-5715131 #35764
聯絡地址 生科二館544室
電子郵件 sctang@life.nthu.edu.tw
個人網站 http://www.3d-histology.com
職銜 American Gastroenterological Association Fellow
授課領域 生物醫學工程
研究專長 三維醫學組織影像
年度 論文名稱
2019 Shen CN, Goh KS, Huang CR, Chiang TC, Lee CY, Jeng YM, Peng SJ, Chien HJ, Chung MH, Chou YH, Hsieh CC, Kulkarni S, Pasricha PJ, Tien YW*, and Tang SC*. Lymphatic vessel remodeling and invasion in pancreatic cancer progression. EBioMedicine, 2019. Accepted
2019 Chien HJ, Chiang TC, Peng SJ, Chung MH, Chou YH, Lee CY, Jeng YM, Tien YW, and Tang SC*. Human pancreatic afferent and efferent nerves: mapping and 3-D illustration of exocrine, endocrine, and adipose innervation. American Journal of Physiology - Gastrointestinal and Liver Physiology, 2019. Accepted
2018 Tang SC*, Shen CN*, Lin PY, Peng SJ, Chien HJ, Chou YH, Chamberlain CE, and Pasricha PJ. Pancreatic neuro-insular network in young mice revealed by 3-D panoramic histology. Diabetologia. 61:158-167, 2018
2018 Tang SC*, Baeyens L, Shen CN, Peng SJ, Chien HJ, Scheel DW, Chamberlain CE, and German MS. Human pancreatic neuro-insular network in health and fatty infiltration. Diabetologia, 61:168-181, 2018
2018 Tang SC*, Jessup CF*, and Campbell-Thompson M*. The role of accessory cells in islet homeostasis. Current Diabetes Reports. 18(11):117, 2018. Review
2018 Peng SJ and Tang SC*. Nature Reviews Endocrinology, Cover image 2019 Jan-Dec, all twelve issues: Peri-islet vasodilation and lymphocytic infiltration in experimental type 1 diabetes mellitus. Winner of 2018 Nature Reviews cover image competition (https://www.nature.com/nrendo/volumes/15/issues/1)
2017 Tang SC, Peng SJ, Baeyens L and German MS. Nature Reviews Endocrinology, Cover image 2017 Jan-Dec, all twelve issues: Human pancreatic microenvironment in type 2 diabetes mellitus. http://www.nature.com/nrendo/journal/v13/n1/index.html
2017 Kulkarni S, Micci MA, Leser J, Shin C, Tang SC, Fu YY, Liu L, Li Q, Saha M, Li C, Enikolopov G, Becker L, Rakhilin N, Anderson M, Shen X, Dong X, Butte MJ, Song H, Southard-Smith EM, Kapur RP, Bogunovic M, Pasricha PJ. Adult enteric nervous system in health is maintained by a dynamic balance between neuronal apoptosis and neurogenesis. Proc Natl Acad Sci USA,114: E3709-E3718, 2017. (Contribution: application of 3-D histology to investigate enteric nervous system)
2016 Chien HJ, Peng SJ, Hua TE, Kuo CH, Juang JH, and Tang SC. 3-D imaging of islets in obesity: formation of the islet-duct complex and neurovascular remodeling in young hyperphagic mice. International Journal of Obesity, 40: 685-697, 2016 (5 of 81 in NUTRITION & DIETETICS)
2016 Lin PY, Peng SJ, Shen CN, Pasricha PJ, and Tang SC. PanIN-associated pericyte, glial, and islet remodeling in mice revealed by 3-D pancreatic duct lesion histology. American Journal of Physiology - Gastrointestinal and Liver Physiology, 311: G412–G422, 2016
2015 Liu YA, Chung YC, Shen MY, Pan ST, Kuo CW, Peng SJ, Pasricha PJ, and Tang SC. Perivascular interstitial cells of Cajal in human colon. Cellular and Molecular Gastroenterology and Hepatology, 1(1):102-119, 2015. American Gastroenterological Association journal
2015 Peng SJ and Tang SC. Nature Reviews Nephrology, Cover image 2015 Jan-Dec, all twelve issues: Projection of mouse renal pericytes and their association with glomeruli. http://www.nature.com/nrneph/journal/v11/n12/index.html
2015 Juang JH, Kuo CH, Peng SJ, and Tang SC. 3-D imaging reveals participation of donor islet Schwann cells and pericytes in islet transplantation and graft neurovascular regeneration. EBioMedicine, 2:109-119, 2015. Cover image of February issue
2014 Hsu CT and Tang SC. Nature Reviews Endocrinology, Cover image 2014 Jan-Dec, all twelve issues: Mouse islet Schwann cell network. http://www.nature.com/nrendo/journal/v10/n1/index.html
2014 Juang JH, Peng SJ, Kuo CH, and Tang SC. 3D islet graft histology: panoramic imaging of neural plasticity in sympathetic reinnervation of transplanted islets under the kidney capsule. American Journal of Physiology - Endocrinology and Metabolism, 306:E559-E570, 2014
2014 Tang SC*, Peng SJ, and Chien HJ. Imaging of the islet neural network. Diabetes, Obesity and Metabolism. Review, 2014. (IF: 6.715)
2013 Fu YY, Peng SJ, Lin HY, Pasricha PJ, and Tang SC. 3-D imaging and illustration of mouse intestinal neurovascular complex. American Journal of Physiology - Gastrointestinal and Liver Physiology. 304:G1-G11, 2013 (Cover image)
2013 Liu YA, Chung YC, Pan ST, Shen MY, Hou YC, Peng SJ, Pasricha PJ, and Tang SC. 3-D imaging, illustration, and quantitation of enteric glial network in transparent human colon mucosa. Neurogastroenterology & Motility. 25:e324-338, 2013
2013 Tang SC*, Chiu YC, Hsu CT, Peng SJ, and Fu YY. Plasticity of Schwann cells and pericytes in response to islet injury in mice. Diabetologia. 56:2424-2434, 2013 (Cover image of November issue)
2013 Hua TE, Yang TL, Yang WC, Liu KJ, and Tang SC. 3-D neurohistology of transparent tongue in health and injury with optical clearing. Frontiers in Neuroanatomy, 7:36 (10 pages), 2013
2012 Liu YA, Chung YC, Pan ST, Hou YC, Peng SJ, Pasricha PJ, and Tang SC. 3-D illustration of network orientations of interstitial cells of Cajal subgroups in human colon as revealed by deep-tissue imaging with optical clearing. American Journal of Physiology - Gastrointestinal and Liver Physiology. 302:G1099-G1110, 2012 (selected as featured article on the May 15 issue: "3-D illustration of ICC network orientations")
2012 Chiu YC, Hua TE, Fu YY, Pasricha PJ, and Tang SC. 3-D imaging and illustration of the perfusive mouse islet sympathetic innervation and its remodelling in injury. Diabetologia. 55:3252-3261, 2012 (Diabetologia commissioned a commentary “Islet nerves in focus – defining their neurobiological and clinical role” 55:3152-3154, 2012 http://www.ncbi.nlm.nih.gov/pubmed/23001378 to accompany this paper. Also, this article is selected as ‘Up Front’ to be included at the front of the December 2012 issue)
2011 Liu YA, Chen Y, Chiang AS, Peng JS, Pasricha PJ, and Tang SC. Optical clearing improves the imaging depth and signal-to-noise ratio for digital analysis and 3-dimensional projection of the human enteric nervous system. Neurogastroenterology & Motility. 23:e446-457, 2011 (This article is highlighted by Nature Reviews Gastroenterology & Hepatology 8, 600: Improving 3D imaging of the enteric nervous system)
2011 Tseng SJ, Chen ZH, and Tang S. Application of heparinized cellulose matrices for substrate-mediated bFGF peptide and transgene delivery to stimulate cellular proliferation. Cellulose. 18: p95-104, 2011
2010 Fu YY and Tang SC. At the movies: 3-dimensional technology and gastrointestinal histology. Gastroenterology, 139(4): p1100-1105, 2010
2010 Tang SC, Fu YY, Lo WF, Hua TE, and Tuan HY. Vascular labeling of luminescent gold nanorods enables 3-D microscopy of mouse intestinal capillaries. ACS Nano, 4(10):6278-84, 2010
2010 Fu YY and Tang SC. Optical clearing facilitates integrated 3D visualization of mouse ileal microstructure and vascular network with high definition. Microvascular Research, 80(3):512-21, 2010
2010 Fu YY, Lu CH, Lin CW, Juang JH, Enikolopov G, Sibley E, Chiang AS, Tang SC. Three-dimensional optical method for integrated visualization of mouse islet microstructure and vascular network with subcellular-level resolution. Journal of Biomedical Optics. 15(4), Article Number: 046018 (9 pages), 2010
2009 Fu YY, Lin CW, Enikolopov G, Sibley E, Chiang AS, and Tang SC. Microtome-free 3-dimensional confocal imaging method for visualization of mouse intestine with subcellular-level resolution. Gastroenterology. 137(2): p453-465, 2009
2009 Tseng SJ, Lee YH, Chen ZH, Lin HH, Lin CY, and Tang SC. Integration of optical clearing and optical sectioning microscopy for three dimensional imaging of natural biomaterial scaffolds in thin sections. Journal of Biomedical Optics. 14(4), Article Number: 044004 (9 pages), 2009
2008 Wang ZH, Chien WC, Yue TW and Tang SC. Application of heparinized cellulose affinity membranes in recombinant adeno-associated virus serotype 2 binding and delivery. Journal of Membrane Science. 310: p141-148, 2008
2008 Chen CA, Lo CK, Lin BL, Sibley E, and Tang SC. Application of doxorubicin-induced rAAV2-p53 gene delivery in combined chemotherapy and gene therapy for hepatocellular carcinoma. Cancer Biology & Therapy. 7(2): p303-309, 2008
2008 Tseng SJ, Chuang CJ and Tang SC. Electrostatic immobilization of DNA polyplexes on small intestinal submucosa for tissue substrate-mediated transfection. Acta Biomaterialia. 4: p799-807, 2008
2008 Fu YY, Sibley E, and Tang SC. Transient cytochalasin-D treatment induces apically administrated rAAV2 across tight junctions for transduction of enterocytes. Journal of General Virology. 89: p3304-3308, 2008
2008 Li H, Shih WH, Shih WY, Chen L, Tseng SJ and Tang SC. Transfection of aqueous CdS quantum dots using polyethylenimine. Nanotechnology. 19, Article Number: 475101 (8 pages), 2008
2007 Yue TW, Chien WC, Tseng SJ and Tang SC. EDC/NHS-mediated heparinization of small intestinal submucosa for recombinant adeno-associated virus serotype 2 binding and transduction. Biomaterials. 28(14): p2350-2357, 2007
2007 Tseng SJ and Tang SC. Development of poly(amino ester glycol urethane)/siRNA polyplexes for gene silencing. Bioconjugate Chemistry. 18(5): p1383-1390, 2007
2007 Tseng SJ and Tang SC. Synthesis and characterization of a novel transfection reagent poly(amino ester glycol urethane). Biomacromolecules. 8(1): p50-58, 2007
國家 學校名稱 系所 學位 期間
USA Stanford University School of Medicine Pediatric Gastroenterology Postdoctoral Fellow 2004.01 ~ 2004.12
USA Georgia Institute of Technology Chemical & Biomolecular Engineering Ph.D. 1998.09 ~ 2003.12
National Cheng Kung University, Taiwan Chemical Engineering M.S. 1992.09 ~ 1994.05
National Cheng Kung University, Taiwan Chemical Engineering B.S. 1988.09 ~ 1992.05
服務機關名稱 單位 職務 期間
National Tsing Hua University, Taiwan Institute of Biotechnology Professor 2012.02 ~ 迄今
National Tsing Hua University, Taiwan Department of Medical Science Professor 2012.02 ~ 迄今
National Tsing Hua University, Taiwan Chemical Engineering Professor (joint appointment) 2012.02 ~ 迄今
National Tsing Hua University, Taiwan Chemical Engineering Professor 2011.08 ~ 2012.01
National Tsing Hua University, Taiwan Chemical Engineering Associate Professor 2008.08 ~ 2011.07
National Tsing Hua University, Taiwan Chemical Engineering Assistant Professor 2005.08 ~ 2008.07
Nanyang Technological University, Singapore Chemical & Biomolecular Engineering Assistant Professor 2005.01 ~ 2005.07