楊嘉鈴
姓名 楊嘉鈴
職稱 教授
聯絡電話 03-5742756
實驗室分機 03-5715131#33487
聯絡地址 生科二館414室
電子郵件 jlyang@life.nthu.edu.tw
個人網站 https://www.facebook.com/yjl41533487/?modal=admin_todo_tour
職銜 生科院學士班主任
授課領域 分子癌病、基因毒理、核酸修補、分子生物學
研究專長 分子癌病、基因毒理、核酸修補、分子生物學
年度 論文名稱
2010 Yen, A.H. and Yang, J.L.* , Cdc20 Proteolysis Requires p38 MAPK Signaling and Cdh1-Independent APC/C Ubiquitination During Spindle Assembly Checkpoint Activation by Cadmium, Journal of Cellular Physiology , 223, 2, pp327-334, (SCI)
2009 Wang, C.Y., Wang, Y.T., Tzeng, D.W. and Yang, J.L.* , Lead acetate induces EGFR activation upstream of SFK and PKC alpha linkage to the Ras/Raf-1/ERK signaling, Toxicology and Applied Pharmacology, 235, 2, pp244-252, (SCI)
2008 Wang, C.Y., Lin, Y.W. and Yang, J.L.* , Activation of protein kinase C alpha signaling prevents cytotoxicity and mutagenicity following lead acetate in CL3 human lung cancer cells, Toxicology, 250, 1, pp55-61, (SCI)
2008 Li, J.P., Wang, C.Y., Tang, Y.A., Lin, Y.W. and Yang, J.L.* , Role of extracellular signal-regulated kinase (ERK) signaling in nucleotide excision repair and genotoxicity in response to As(III) and Pb(II), Pure and Applied Chemistry , 80, 12, pp2735-2750, (SCI)
2007 Li, J.P. and Yang, J.L.*, Cyclin B1 proteolysis via p38 MAPK signaling participates in G2 checkpoint elicited by arsenite, Journal of Cellular Physiology , 212, 2, pp481-488, (SCI)
2006 Lin, Y.W. and Yang, J.L.* , Cooperation of ERK and SCFSkp2 for MKP-1 destruction provides a positive-feedback regulation of proliferating signaling, Journal of Biological Chemistry, 281, 2, pp915-926, (SCI)
2006 Li, J.P., Lin, J.C. and Yang, J.L.*, ERK activation in arsenite-treated G1-enriched CL3 cells contributes to survival, DNA repair inhibition, and micronucleus formation, Toxicological Sciences, 89, 1, pp164-172, (SCI)
2006 Hsiue, G.H., Wang, C.H., Lo, C.L., Li, J.P. and Yang, J.L. , Environmental-sensitive micelles based on poly(2-ethyl-2-oxazoline)-b-poly(L-lactide) diblock copolymer for application in drug delivery, International Journal of Pharmaceutics, 317, 1, pp69-75, (SCI)
2004 Ko JC, WangYT, and Yang JL* (2004) Dual and opposing roles of ERK in regulating G1 and S-G2/M delays in A549 cells caused by hyperoxia. Exp Cell Res 297: 472-483
2003 Lin YW, Chuang SM, Yang JL* (2003) ERK1/2 achieves sustained activation by stimulating MAPK phosphatase-1 degradation via the ubiquitin-proteasome pathway. J Biol Chem 278: 21534-21541
2003 Lin YW, Chuang SM, Yang JL* (2003)Persistent activation of ERK1/2 by lead acetate increases nucleotide excision repair synthesis and confers anti-cytotoxicity and anti-mutagenicity. Carcinogenesis 24: 53-61
2003 Chuang SM, Wang IC, Hwua YS,Yang JL* (2003) Short-term depletion of catalase suppresses cadmium-elicited c-Jun N-terminal kinase activation and apoptosis: role of protein phosphatases. Carcinogenesis 24: 7-15
2001 Yang JL*, Chuang SM(2001) Comparison of roles of three mitogen-activated protein kinases induced by chromium(VI) and cadmium in non-small-cell lung carcinoma cells.Mol Cell Biochem 222: 85-95
2001 Chao JI, Yang JL* (2001) Alteration of cadmium-induced mutational spectrum by catalase depletion in Chinese hamster ovary-K1 cells. Mutat. Res.498: 7-18
2001 Chao JI, Yang JL* (2001) Opposite roles of ERK and p38 mitogen-activated protein kinases in cadmium-induced genotoxicity and mitotic arrest. Chem. Res. Toxicol. 14: 1193-1202
2000 Chuang SM, Liou GY, Yang JL* (2000) Activation of JNK, p38 and ERK mitogen-activated protein kinases by chromium(VI) is mediated through oxidative stress but does not affect cytotoxicity. Carcinogenesis 21: 1491-1500
2000 Chuang SM, Wang IC, Yang JL* (2000) Roles of JNK, p38 and ERK mitogen-activated protein kinases in the growth inhibition and apoptosis induced by cadmium. Carcinogenesis 21: 1423-1432.
國家 學校名稱 系所 學位 期間
中華民國 中興大學 土壤學系 學士 1975.09 ~ 1979.06
美國 密西根州立大學 生物化學 博士 1983.09 ~ 迄今
服務機關名稱 單位 職務 期間
國立清華大學 生物科技所 教授 2002.08 ~ 迄今
國立清華大學 生命科學系 教授 1996.08 ~ 迄今
國立清華大學 生物醫學所 副教授 1991.08 ~ 1996.07
中央研究院 生物醫學所 博士後研究 1989.02 ~ 1991.07
密西根州立大學 癌病學研究室 博士後研究 1988.01 ~ 1989.01