張壯榮
姓名 張壯榮
職稱 副教授
聯絡電話 03-5742776
聯絡地址 生科二館506室
電子郵件 crchang@life.nthu.edu.tw
個人網站 https://crclabatnthu.weebly.com/
授課領域 分子生物、胞器傳輸、表態遺傳、酵母菌細胞與生化學
研究專長 老化、癌症等疾病進程與粒線體動態及活性調控之關聯、酵母菌乾燥耐受性
年度 論文名稱
2020 Chuang KC, Chang CR, Chang SH, Huang SW, Chuang SM, Li ZY, Wang ST, Kao JK, Chen YJ, Shieh JJ., Imiquimod-induced ROS production disrupts the balance of mitochondrial dynamics and increases mitophagy in skin cancer cells. (Available online 2020 April 23), J. Dermatol. Sci., (SCI)
2019 Kurylenko O, Rozenfelde L, Khroustalyova G, Vasylyshyn R, Ruchala J, Chang CR, Daugelavicius R, Sibirny A, Rapoport A., Anhydrobiosis in yeasts: glutathione synthesis by yeast Ogataea (Hansenula) polymorphacells after their dehydration-rehydration., J Biotechnol., 304, pp28-30, (SCI)
2019 Kuo YY, Huo C, Lin CY, Lin HP, Liu JS, Wang WC, Chang CR*, Chuu CP., Caffeic acid phenethyl ester suppresses androgen receptor signaling and stability via inhibition of phosphorylation on Ser81 and Ser213., Cell Commun Signal., 17, 1, pp100-, (SCI)
2019 Chen YC, Cheng TH, Lin WL, Chen CL, Yang WY, Blackstone C, Chang CR*., Srv2 is a pro-fission factor that modulates yeast mitochondrial morphology and respiration by regulating actin assembly., iScience, 11, pp305-317, (SCI)
2018 Lin CY, Jan YJ, Kuo LK, Wang BJ, Huo C, Jiang SS, Chen SC, Kuo YY, Chang CR, Chuu CP., Elevation of Androgen Receptor Promotes Prostate Cancer Metastasis via Induction of EMT and Reduction of KAT5., Cancer Sci., 109, 11, pp3564-3574, (SCI)
2018 Kulikova-Borovikovaa D, Khroustalyovaa G, Chang CR, Daugelaviciusc R, Yurkivd M, Ruchalae J, Sibirnyd A, Rapoporta A., Anhydrobiosis in yeast: Glutathione overproduction improves resistance to dehydration of a recombinant Ogataea (Hansenula) polymorpha strain., Process Biochem., 71, pp41-44, (SCI)
2016 Chen YJ, Chuang YC, Chuang CN, Cheng YS, Chang CR, Leng CH, and Wang TF. , S. cerevisiae Mre11 recruits conjugated SUMO moieties to facilitate the assembly and function of the Mre11-Rad50-Xrs2 complex., Nucleic Acids Res., 44, 5, pp2199-2213, (SCI)
2015 Lo MC, Chen MH, Lee WS, Lu CI, Chang CR, Kao SH, Lee HM., Nε-(carboxymethyl) lysine-induced mitochondrial fission and mitophagy causes decreased insulin secretion from beta cells., Am J Physiol Endocrinol Metab., 309, 10, ppE829-39, (SCI)
2015 Chien L, Chen WK, Liu ST, Chang CR, Kao MC, Chen KW, Chiu SC, Hsu ML, Hsiang IC, Chen YJ, Chen L., Low-dose ionizing radiation induces mitochondrial fusion and increases expression of mitochondrial complexes I and III in hippocampal neurons., Oncotarget, 6, 31, pp30628-39, (SCI)
2015 Kuo YY, Jim WT, Su LC, Chung CJ, Lin CY, Huo C, Tseng JC, Huang SH, Lai CJ, Chen BC, Wang BJ, Chan TM, Lin HP, Chang WW, Chang CR, Chuu CP., Caffeic acid phenethyl ester is a potential therapeutic agent for oral cancer., Int. J. Mol. Sci., 16, 5, pp10748-10766, (SCI)
2014 Wang IH, Chen HY, Wang YH, Chang KW, Chen YC, Chang CR*, Resveratrol modulates mitochondria dynamics in replicative senescent yeast cells., PLoS One, 9, 8, ppe104345-, (SCI)
2013 Huang TL, Hsu HC, Chen HC, Lin HC, Chien CY, Fang FM, Huang CC, Chang HW, Chang WN, Huang CR, Tsai NW, Kung CT, Wang HC, Lin WC, Cheng BC, Su YJ, Chang YT, Chang CR*, Tan TY, Lu CH., Long-term effects on carotid intima-media thickness after radiotherapy in patients with nasopharyngeal carcinoma., Radiat Oncol, 8, 1, pp261-, (SCI)
2013 Huang CC, Huang TL, Hsu HC, Chen HC, Lin HC, Chien CY, Fang FM, Chang HW, Tsai NW, Chang WN, Chen SF, Lin TK, Tan TY, Chang CR, Wang HC, Lin WC, Lu CH., Long-term effects of neck irradiation on cardiovascular autonomic function: A study in nasopharyngeal carcinoma patients after radiotherapy., Muscle Nerve, 47, 3, pp344-350, (SCI)
2012 Liu CR, Chang CR, Chern Y, Wang TH, Hsieh WC, Shen WC, Chang CY, Chu IC, Deng N, Cohen SN, Cheng TH., Spt4 is selectively required for transcription of extended trinucleotide repeats. , Cell, 148, 4, pp690-701, (SCI)
2012 Jheng HF, Tsai PJ, Guo SM, Kuo LH, Chang CS, Su IJ, Chang CR, Tsai YS. , Mitochondrial fission contributes to mitochondrial dysfunction and insulin resistance in skeletal muscle., Mol Cell Biol., 32, 2, pp309-19, (SCI)
2011 Blackstone C, Chang CR, Mitochondria unite to survive., Nat Cell Biol., 13, 5, pp521-22, (SCI)
2010 Chang CR, Manlandro CM, Arnoult D, Stadler J, Posey AE, Hill RB, Blackstone C., A lethal de novo mutation in the middle domain of the dynamin-related GTPase Drp1 impairs higher-order assembly and mitochondrial division., J Biol Chem., 285, 42, pp32494-503, (SCI)
2010 Chang CR, Blackstone C, Dynamic regulation of mitochondrial fission through modification of the dynamin-related protein Drp1, Ann N Y Acad Sci. , 1201, pp34-9, (SCI)
2009 Figueroa-Romero C, Iñiguez-Lluh JA, Stadler J, Chang CR, Arnoult D, Keller PJ, Hong Y, Blackstone C, Feldman EL., SUMOylation of the mitochondrial fission protein Drp1 occurs at multiple nonconsensus sites within the B domain and is linked to its activity cycle, FASEB J., 23, 11, pp3917-27, (SCI)
2008 Cereghetti GM, Stangherlin A, Martins de Brito O, Chang CR, Blackstone C, Bernardi P, Scorrano L. , Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria. , Proc Natl Acad Sci U S A., 105, 41, pp15803-8, (SCI)
2007 Chang CR, Blackstone C. , Drp1 phosphorylation and mitochondrial regulation. , EMBO Rep. , 12, pp1088-9, (SCI)
2007 Chang CR, Blackstone C. , Cyclic AMP-dependent protein kinase phosphorylation of Drp1 regulates its GTPase activity and mitochondrial morphology. , J Biol Chem., 282, 30, pp21583-7, (SCI)
2005 Chang CR, Wu CS, Hom Y, Gartenberg MR. , Targeting of cohesin by transcriptionally silent chromatin. , Genes Dev. , 19, 24, pp3031-42, (SCI)
2000 Cheng TH, Chang CR, Joy P, Yablok S, Gartenberg MR. , Controlling gene expression in yeast by inducible site-specific recombination. , Nucleic Acids Res., 28, 24, ppE108-, (SCI)
1999 Ho YS, Lee HM, Chang CR, Lin JK. , Induction of Bax protein and degradation of lamin A during p53-dependent apoptosis induced by chemotherapeutic agents in human cancer cell lines. , Biochem Pharmacol., 57, 2, pp143-54, (SCI)
國家 學校名稱 系所 學位 期間
美國 羅格斯大學/紐澤西醫學與牙科大學 細胞與分子藥理學 博士 1998.09 ~ 2004.09
中華民國 台北醫學大學 醫學檢驗暨生物技術學系 學士 1990.09 ~ 1994.09
服務機關名稱 單位 職務 期間
亞洲粒線體醫學暨研究學會 2019.10 ~ 迄今
台灣粒線體醫學暨研究學會 2016.01 ~ 迄今
台灣自由基學會 2015.10 ~ 2018.10
美國國家衛生研究院 National Institute of Neurological Disorders and Stroke, NIH 博士後研究員 2005.05 ~ 2009.02
紐澤西醫學與牙科大學 Department of Pharmacology, RWJMS 博士後研究員 2004.09 ~ 2005.04
類別 年度 獎項名稱 頒獎單位
校內榮譽 2012 生命科學院教學績優獎 國立清華大學生命科學院
校內榮譽 2011 生命科學院新進教師研究獎 國立清華大學生命科學院
校外榮譽 2006 Fellow Award for Research Excellence 美國國家衛生研究院
校外榮譽 2001 Young Investigator Award 紐澤西醫學與牙科大學